Biofabrication is based on a relatively new method known as ‘3D bioprinting.’ This procedure begins with an architectural design based on the composition of the bone tissue. This design is then sent into a bioprinter, which deposits tiny layers of cells, nutrients, and matrix components in order to progressively build up and form bone tissues. The matrix components are essential to support and protect cells throughout the vertical construction of the tissue, as well as to fill empty spaces within the tissue.
As a result, it can be employed in a variety of applications. A 3D composite scaffold is one of the most advanced alternatives to bone substitutes since it allows cells to manage their microenvironment, proliferate, and migrate during the formation of new bone. Various organic and inorganic biomaterials may be combined or used alone to create an appropriate bone scaffold. These osteoconductive scaffolds can be modified using a variety of cell- or growth factor-based tissue engineering approaches to stimulate osteogenesis and to provide osteoinductive properties.
Custom-made, individualized, and anatomically shaped bone scaffolds are frequently required for the treatment of abnormalities in the craniofacial region. By layering materials, 3D printing technology enables the fabrication of complex, precise and personalized bone scaffolds. The manufacturing technology has significant potential in the field of regenerative medicine since it allows the creation of customisable and defect-filled bone scaffolds for bone tissue regeneration.
SCAFFOLD CAD DESIGN SERVICES
Recent studies have shown the importance of the geometry of 3D bioprinted bone scaffolds on the mechanical properties and the regenerative potential. Various regular and irregular geometrical features, with and without a gradient, can be introduced into the 3D printed scaffold design. Osseum4D team is delighted to offer CAD design services for 3D bioprinting applications.
3D BIOPRINTING SERVICES
PLA, PGA, and PCL thermoplastic materials can be combined with HA, β-TCP, and bioglasses to produce the inks and 3D bioprint using inkjet technology. Optimal mechanical properties and resorption rates can be achieved by the different mixtures of the materials in the composite scaffolds. Osseum4D team can offer various 3D bioprinting services. Also, other commercially available bioinks (alginate-, collagen-, hyaluronic acid-based) can be utilized, e.g., https://www.cellink.com/